Mwele Ntuli Malecela (26 March 1963 – 10 February 2022) was a Tanzanian civil servant who was a senior United Nations official and the director of the Department of Control of Neglected Tropical Diseases at the World Health Organization Headquarters in Geneva, Switzerland.

Following her graduating in Zoology at the University of Dar es Salaam, she joined Tanzania's National Institute for Medical Research (NIMR) in 1987, where she worked at the Amani Center to conduct research on lymphatic filariasis. Following this, she continued her education at the London School of Hygiene & Tropical Medicine, where she completed her MSc (1990) and PhD (1995). She continued her research at NIMR thereafter, and became Director of Research Coordination and Promotion (DRCP) in 1998 before moving on to become the Director of the Lymphatic Filariasis program in 2000, which is now functional in 53 districts. In 2010 she was appointed NIMR's Director General, and was the first woman to hold this position. In June 2015, she went on sabbatical to pursue her political aspirations.

In 2017, she joined WHO’s Regional Office for Africa in April 2017 as the Director in the Office of the Regional Director (RD) responsible for providing policy, managerial and diplomatic advice to the RD, coordinating and facilitating the plan of work for all units under the RD's Office Cluster, and monitoring the implementation of policy decisions of WHO governing bodies. In October 2018 the Director General of WHO, Dr Tedros Adhanom Ghebreyesus, appointed her Director of the Department of Control of Neglected Tropical Diseases, based at the Organization's headquarters in Geneva.